Copper-mediated cross-coupling of aryl boronic acids and alkyl thiols

Org Lett. 2000 Jul 13;2(14):2019-22. doi: 10.1021/ol005832g.


[reaction: see text] The cross-coupling of aryl boronic acids and alkanethiols mediated by copper(II) acetate and pyridine in anhydrous dimethylformamide affords aryl alkyl sulfides in good yield with a wide variety of substituted aryl boronic acids. The method is applicable to the synthesis of aryl sulfides of cysteine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Boronic Acids / chemistry*
  • Catalysis
  • Copper / chemistry*
  • HIV Protease Inhibitors / chemical synthesis
  • HIV Protease Inhibitors / chemistry
  • Nelfinavir / chemical synthesis
  • Nelfinavir / chemistry
  • Sulfhydryl Compounds / chemistry*


  • Boronic Acids
  • HIV Protease Inhibitors
  • Sulfhydryl Compounds
  • Copper
  • Nelfinavir