Aberrant processing of oxidative DNA damage in systemic lupus erythematosus

Biochem Biophys Res Commun. 2000 Jul 14;273(3):894-8. doi: 10.1006/bbrc.2000.3078.


Defective DNA damage processing has been reported in systemic lupus erythematosus (SLE). Vitamin C may modulate formation/removal of the oxidative DNA lesion 8-oxo-2'-deoxyguanosine (8-oxodG). Baseline levels of 8-oxodG measured in SLE serum, urine and PBMC DNA did not differ significantly from healthy subjects. In contrast to healthy subjects, no significant decrease in PBMC 8-oxodG or increase in urinary 8-oxodG was noted in vitamin C supplemented SLE patients. A significant, although attenuated, increase in serum 8-oxodG was detected in SLE patients, compared to healthy subjects. These data support putative abnormalities in the repair/processing of 8-oxodG in SLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Adult
  • Aged
  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / blood
  • DNA Damage*
  • Deoxyguanosine / analogs & derivatives
  • Deoxyguanosine / blood
  • Deoxyguanosine / urine
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / genetics*
  • Middle Aged
  • Oxidative Stress*


  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine
  • Ascorbic Acid