Serum alpha-fetoprotein levels in Beckwith-Wiedemann syndrome

J Pediatr. 2000 Jul;137(1):123-7. doi: 10.1067/mpd.2000.106217.


We conducted a retrospective study that compared serial alpha-fetoprotein (AFP) concentrations obtained from 22 children with Beckwith-Wiedemann syndrome (BWS) with levels established for healthy children. The AFP concentration is greater in patients with BWS and declines during the postnatal period at a significantly slower rate than what is reported in healthy children. AFP levels obtained in the course of routine tumor screening in children with BWS should be interpreted with a normal curve established specifically for BWS rather than with previously published data for healthy infants and children.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Beckwith-Wiedemann Syndrome / blood*
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Retrospective Studies
  • alpha-Fetoproteins / analysis*


  • alpha-Fetoproteins