Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype

Neurology. 2000 Jul 12;55(1):134-6. doi: 10.1212/wnl.55.1.134.

Abstract

The epsilon4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD. The authors compared longitudinal rates of change in hippocampal volume as a function of APOE genotype in nondemented elderly individuals. Rate of volumetric loss was significantly greater among epsilon4+ compared with epsilon4- individuals. These results indicate that individuals positive for the APOE epsilon4 allele may show a greater rate of hippocampal atrophy than their epsilon4- counterparts, even in the absence of a diagnosis of AD.

MeSH terms

  • Age Factors
  • Aged
  • Alleles
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology*
  • Apolipoproteins E / genetics*
  • Female
  • Genotype
  • Hippocampus / pathology*
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male

Substances

  • Apolipoproteins E