Recovery from chronic hepatitis C in long-term responders to ribavirin plus interferon alfa

Lancet. 2000 Jul 1;356(9223):41. doi: 10.1016/S0140-6736(00)02434-X.

Abstract

In 45 sustained responders to interferon alfa and ribavirin, we found long-lasting elimination of hepatitis C virus RNA from serum and liver, together with histopathological improvement, suggesting complete recovery from chronic hepatitis C.

Publication types

  • Clinical Trial
  • Letter

MeSH terms

  • Alanine Transaminase / blood
  • Antiviral Agents / therapeutic use*
  • Biopsy
  • Chronic Disease
  • Drug Therapy, Combination
  • Female
  • Hepacivirus / genetics
  • Hepacivirus / isolation & purification
  • Hepatitis C / diagnosis
  • Hepatitis C / drug therapy*
  • Humans
  • Interferon-alpha / therapeutic use*
  • Liver / enzymology
  • Liver / pathology
  • Liver / virology
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Predictive Value of Tests
  • RNA, Viral / blood
  • Ribavirin / therapeutic use*
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Interferon-alpha
  • RNA, Viral
  • Ribavirin
  • Alanine Transaminase