Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
, 321 (7254), 142-7

Sources of Toxoplasma Infection in Pregnant Women: European Multicentre Case-Control Study. European Research Network on Congenital Toxoplasmosis

Affiliations
Multicenter Study

Sources of Toxoplasma Infection in Pregnant Women: European Multicentre Case-Control Study. European Research Network on Congenital Toxoplasmosis

A J Cook et al. BMJ.

Abstract

Objective: To determine the odds ratio and population attributable fraction associated with food and environmental risk factors for acute toxoplasmosis in pregnancy.

Design: Case-control study.

Setting: Six large European cities.

Participants: Pregnant women with acute infection (cases) detected by seroconversion or positive for anti-Toxoplasma gondii IgM were compared with pregnant women seronegative for toxoplasma (controls).

Main outcome measures: Odds ratios for acute infection adjusted for confounding variables; the population attributable fraction for risk factors.

Results: Risk factors most strongly predictive of acute infection in pregnant women were eating undercooked lamb, beef, or game, contact with soil, and travel outside Europe and the United States and Canada. Contact with cats was not a risk factor. Between 30% and 63% of infections in different centres were attributed to consumption of undercooked or cured meat products and 6% to 17% to soil contact.

Conclusions: Inadequately cooked or cured meat is the main risk factor for infection with toxoplasma in all centres. Preventive strategies should aim to reduce prevalence of infection in meat, improve labelling of meat according to farming and processing methods, and improve the quality and consistency of health information given to pregnant women.

Similar articles

  • Risk Factors for Toxoplasma Gondii Infection in the United States
    JL Jones et al. Clin Infect Dis 49 (6), 878-84. PMID 19663709.
    In the United States, exposure to certain raw or undercooked foods and exposure to kittens are risk factors for T. gondii infection. Knowledge of these risk factors will …
  • Risk Factors for Toxoplasma Infection in Pregnancy: A Case-Control Study in France
    L Baril et al. Scand J Infect Dis 31 (3), 305-9. PMID 10482062.
    Each year an estimated 4900 cases of primary Toxoplasma infection occur in pregnant women in France, a country with a high prevalence. Since 1992 all pregnant women at ri …
  • [Investigation on Toxoplasma gondii Infection and Awareness of Toxoplasmosis-Related Knowledge in Women With Poor Pregnant Outcomes in Wuxi City]
    F Yun et al. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 28 (6), 664-668. PMID 29469258.
    [摘要]目的 调查无锡地区不良妊娠结局妇女弓形虫感染情况及弓形虫病相关知识知晓率。 方法 以2011年1月 至2015年12月无锡市217例不良妊娠结局妇女作为研究对象 (试验组), 以250例正常妊娠妇女作为对照。采用ELISA 法检测并比较试验组和对照组血清抗弓形虫抗体阳性率。采用自行设计的问 …
  • Toxoplasmosis in Pregnancy
    JD Kravetz et al. Am J Med 118 (3), 212-6. PMID 15745715. - Review
    Pregnant women who acquire infection from Toxoplasma gondii usually remain asymptomatic, although they can still transmit the infection to their fetuses with severe conse …
  • Preventing Congenital Toxoplasmosis
    A Lopez et al. MMWR Recomm Rep 49 (RR-2), 59-68. PMID 15580732. - Review
    Many cases of congenital toxoplasmosis can be prevented. Specific measures can be taken by women and their health-care providers to decrease the risk for infection during …
See all similar articles

Cited by 150 PubMed Central articles

See all "Cited by" articles

Publication types

Feedback