RANTES gene polymorphism in polymyalgia rheumatica, giant cell arteritis and rheumatoid arthritis

Clin Exp Rheumatol. May-Jun 2000;18(3):391-3.

Abstract

Objective: To investigate whether a biallelic polymorphism (A or G) occurring within the promoter region of the RANTES gene (position-403) is associated with polymyalgia rheumatica (PMR), giant cell arteritis (GCA) and rheumatoid arthritis (RA).

Methods: A PCR-RFLP method was used to genotype cases and controls for this polymorphism. 3 groups of patients were examined; these comprised GCA patients who did not exhibit features of PMR (n = 30), PMR patients who did not exhibit features of GCA (n = 53) and RA patients (n = 99). All patients and controls (n = 65) originated from the area surrounding Lugo, Galicia, NW Spain.

Results: A significant increase in the frequency of allele A was found in PMR patients compared with normal controls. A marginal increase of this allele frequency was observed in RA but not in GCA patients.

Conclusion: This is the first report of an association of a RANTES gene polymorphisms with PMR and RA. Our data suggest a possible role for of RANTES in the development of both PMR and RA.

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Arthritis, Rheumatoid / genetics*
  • Chemokine CCL5 / genetics*
  • Female
  • Gene Frequency
  • Genotype
  • Giant Cell Arteritis / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Restriction Fragment Length*
  • Polymyalgia Rheumatica / genetics*
  • Promoter Regions, Genetic / genetics

Substances

  • Chemokine CCL5