An antimalarial stilbene from Artocarpus integer

Phytochemistry. 2000 Jun;54(4):415-7. doi: 10.1016/s0031-9422(00)00074-1.

Abstract

Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene with an EC50 of 1.7 micrograms/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-trans-ethenyl)chromene , were also isolated. Structures of these compounds were deduced on the basis of their spectral data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects
  • Spectrometry, Mass, Electrospray Ionization
  • Stilbenes / isolation & purification*

Substances

  • 4-(3-methylbut-1-enyl)-3,5,2',4'-tetrahydroxystilbene
  • Antimalarials
  • Stilbenes