Abstract
T4 DNA synthesized in a toluene-treated cell system can act as the genetic donor in a DNA transformation assay. This material transforms a variety of markers at high efficiency. We present evidence that the genetic activity is due to newly synthesized, double-stranded DNA.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Coliphages / growth & development*
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DNA Replication
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DNA Viruses / growth & development
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DNA, Viral / biosynthesis*
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Escherichia coli / drug effects*
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Genetic Linkage
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Helper Viruses
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Mutation
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Nucleic Acid Denaturation
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Toluene / pharmacology*
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Transformation, Genetic
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Virus Replication*