Association of smoking and personality with a polymorphism of the dopamine transporter gene: results from a community survey

Am J Med Genet. 2000 Jun 12;96(3):331-4. doi: 10.1002/1096-8628(20000612)96:3<331::aid-ajmg19>;2-0.


In studies that used mixed volunteer samples, Lerman et al. [1999: Health Psychol 18:14-20] and Sabol et al. [1999: Health Psychol 18:7-13] reported on an association of smoking with a polymorphism of the dopamine transporter gene. We attempted to replicate this association in a nonvolunteer community sample of 861 Caucasians. No associations were found with either smoking initiation or smoking cessation. Sabol et al. [1999] also reported on an association of the dopamine transporter polymorphism with the personality trait of novelty seeking. However, we failed to find any associations with a range of personality traits, including a scale of fun seeking that correlates with novelty seeking. These negative findings suggest that either the original associations are not replicable or that any association is very small.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Australia / epidemiology
  • Carrier Proteins / genetics*
  • Chi-Square Distribution
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins
  • Exploratory Behavior
  • Female
  • Humans
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Nerve Tissue Proteins*
  • Personality / genetics*
  • Personality Inventory
  • Reproducibility of Results
  • Smoking / epidemiology
  • Smoking / genetics*
  • Smoking / metabolism
  • Smoking / psychology
  • Statistics, Nonparametric
  • Surveys and Questionnaires


  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Dopamine