ER stress response: getting the UPR hand on misfolded proteins

Curr Biol. 2000 Jul 13;10(14):R518-21. doi: 10.1016/s0960-9822(00)00583-2.


Unfolded proteins are constantly delivered to the ER lumen, where they must be removed by folding or degradation. Recent studies show that the 'unfolded protein response' controls essentially all aspects of ER function, coordinating these two fates for misfolded proteins in a process necessary for normal cell life.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / metabolism*
  • Models, Biological
  • Protein Denaturation
  • Protein Folding
  • Proteins / chemistry*
  • Proteins / metabolism*
  • Signal Transduction
  • Stress, Physiological / genetics
  • Stress, Physiological / metabolism
  • Transcription, Genetic


  • Proteins