Reinstatement of both a conditioned place preference and a conditioned place aversion with drug primes

Pharmacol Biochem Behav. 2000 Jul;66(3):559-61. doi: 10.1016/s0091-3057(00)00222-7.


In two experiments, we report that the place-conditioning paradigm can be used to demonstrate reinstatement of place preference/aversion by a drug prime following extinction training. In Experiment 1, rats were trained to prefer a chamber paired with morphine. Following extinction training, a morphine drug prime reinstated the morphine place preference. In Experiment 2, a lithium-induced conditioned place aversion was reinstated following extinction training by a lithium prime prior to testing. These results indicate that not only do rewarding drug primes produce reinstatement of learned responses (as demonstrated in the drug self-administration paradigm), but also aversive drug primes reinstate aversive learned responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Opioid / pharmacology
  • Animals
  • Antimanic Agents / pharmacology
  • Conditioning, Psychological / drug effects*
  • Extinction, Psychological / drug effects
  • Learning / drug effects*
  • Lithium Chloride / pharmacology*
  • Male
  • Memory / drug effects
  • Morphine / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Reward


  • Analgesics, Opioid
  • Antimanic Agents
  • Morphine
  • Lithium Chloride