Reboxetine: tolerability and safety profile in patients with major depression

Acta Psychiatr Scand Suppl. 2000;402:37-40. doi: 10.1034/j.1600-0447.2000.02606.x.


Since reboxetine acts selectively on the reuptake of noradrenaline, it has a different side-effects profile than drugs acting predominantly on the serotonin reuptake mechanism. Data from patients treated with reboxetine (n = 1503) or placebo/comparator drugs (n = 1027) show that reboxetine has no significant cardiovascular effects, a low potential for drug interactions, causes no significant impairment of cognitive or motor function and no increase in suicidal ideation. In contrast to certain serotonergic drugs, there is no evidence of any withdrawal syndrome upon abrupt discontinuation or tapering of reboxetine treatment. Sexual dysfunction appears in only a small fraction of the patients and mainly with doses higher than 8 mg daily. The rate of discontinuation due to adverse effects with reboxetine was not significantly different from that observed with placebo in short-term studies. The level of efficacy and apparently favourable tolerability profile makes reboxetine an important alternative in the medical treatment of depressive illness.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenergic Uptake Inhibitors / adverse effects
  • Adrenergic Uptake Inhibitors / therapeutic use*
  • Age Factors
  • Antidepressive Agents / adverse effects
  • Antidepressive Agents / therapeutic use*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Depressive Disorder, Major / drug therapy*
  • Drug Interactions
  • Fluoxetine / therapeutic use
  • Humans
  • Imipramine / therapeutic use
  • Morpholines / adverse effects
  • Morpholines / therapeutic use*
  • Multicenter Studies as Topic
  • Randomized Controlled Trials as Topic
  • Reboxetine
  • Therapeutic Equivalency


  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents
  • Morpholines
  • Fluoxetine
  • Cytochrome P-450 Enzyme System
  • Reboxetine
  • Imipramine