Cathepsin-6, a novel cysteine proteinase showing homology with and co-localized expression with cathepsin J/P in the labyrinthine layer of mouse placenta

Biochem J. 2000 Aug 1;349 Pt 3(Pt 3):689-92. doi: 10.1042/bj3490689.


A novel cysteine proteinase, cathepsin-6, was isolated by RNA differential display from mouse placenta. Cathepsin-6 showed the highest homology with cathepsin J (same as P) and L. The structural features including the catalytic triad of the C1 proteinase family were well conserved in cathepsin-6. The expression of cathepsin-6 and cathepsin J/P was restricted in labyrinthine trophoblasts of the placenta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Cathepsin K
  • Cathepsins / chemistry
  • Cathepsins / genetics
  • Cathepsins / metabolism*
  • DNA Primers
  • Female
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Placenta / enzymology*
  • Pregnancy


  • DNA Primers
  • Cathepsins
  • cathepsin J
  • cathepsin-6
  • Cathepsin K
  • Ctsk protein, mouse

Associated data

  • GENBANK/AF223401