The antitumour activity of methanolic extract of Enicostemma littorale (MEL) has been evaluated against Dalton's ascitic lymphoma (DAL) in swiss albino mice. A significant enhancement of mean survival time of MEL treated tumour bearing mice was found with respect to control group. MEL treatment was found to enhance peritoneal cell counts. When these MEL treated animals underwent i.p. inoculation with DAL cells, tumour cell growth was found to be inhibited. After 14 days of inoculation, MEL is able to reverse the changes in the haemotological parameters, protein and PCV consequent to tumour inoculation.