Repetitive nerve stimulation: effects of recording site and the nature of 'pseudofacilitation'

Clin Neurophysiol. 2000 Aug;111(8):1411-9. doi: 10.1016/s1388-2457(00)00331-x.


Objectives: To describe changes in the waveform of the compound muscle action potential (CMAP) during repetitive nerve stimulation for various recording sites.

Methods: Responses to trains of 10 stimuli given at 0.1, 1, 3, 5, 10 and 30 Hz to the ulnar nerve were recorded simultaneously from 8 hand sites in 15 healthy subjects. Percentile changes of amplitude, duration and area of both negative and positive phases were analyzed.

Results: Duration consistently decreased during the trains. At 30 Hz, the mean amplitude of the negative phase increased on 5 sites but decreased on 3. Area consistently decreased, but least for hypothenar sites. Repeated stimulation causes an alteration in the waveform of the CMAP that consists of 4 elements: (1) shorter duration; (2) changed amplitude of the negative phase (up or down); (3) merging of bifid peaks; (4) changes were more pronounced for positive than negative phases.

Conclusions: As the term 'pseudofacilitation' implies an increase in amplitude, it is often not appropriate. Increased muscle fiber conduction velocity can explain most of the waveform alterations. Movement and shortening of muscles may play additional roles. Consequences for diagnostic yield await a comparison with disease groups.

MeSH terms

  • Action Potentials / physiology
  • Adult
  • Electric Stimulation
  • Electromyography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neural Conduction / physiology*
  • Time Factors
  • Ulnar Nerve / physiology*