Bronchiectasis and homozygous alpha1-antitrypsin deficiency

Chest. 1975 Feb;67(2):233-5. doi: 10.1378/chest.67.2.233.


A 34-year-old woman with homozygous a1-antitrypsin deficiency suffered from progressive, generalized cystic bronchiectasis. Although bronchiectasis was reported in the original monograph on the enzyme inhibitor deficiency, it has received minimal attention since then. Alpha1-antitrypsin levels should be measured in patients with severe bronchiectasis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Bronchiectasis / enzymology*
  • Bronchiectasis / genetics
  • Bronchiectasis / therapy
  • Bronchodilator Agents / therapeutic use
  • Female
  • Homozygote
  • Humans
  • Physical Therapy Modalities
  • Positive-Pressure Respiration
  • Smoking
  • alpha 1-Antitrypsin Deficiency*


  • Anti-Bacterial Agents
  • Bronchodilator Agents