Retrospective study of prion-protein accumulation in tonsil and appendix tissues

Lancet. 2000 May 13;355(9216):1693-4. doi: 10.1016/S0140-6736(00)02243-1.


To identify individuals who could be at high risk of developing vCJD, a sensitive immunohistochemical technique was used to detect prion protein in a retrospective series of over 3000 tonsil and appendix specimens. No positives were detected but further studies are required to help reduce uncertainties about possible future numbers of vCJD cases in the UK.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Appendix / pathology*
  • Creutzfeldt-Jakob Syndrome / epidemiology
  • Creutzfeldt-Jakob Syndrome / pathology*
  • Cross-Sectional Studies
  • Humans
  • Incidence
  • Palatine Tonsil / pathology*
  • Prions / analysis*
  • Retrospective Studies
  • United Kingdom / epidemiology


  • Prions