Iris involvement in primary intraocular lymphoma: report of two cases and review of the literature

Surv Ophthalmol. 2000 May-Jun;44(6):518-26. doi: 10.1016/s0039-6257(00)00118-1.


Non-Hodgkin's lymphoma involves ocular tissues either as a primary tumor or as secondary metastasis from systemic disease. Diagnosis is based on the identification of malignant cells in the eye by biopsy. Although primary intraocular lymphoma cells have been identified in the optic nerve, ciliary body, and iris of a small number of patients by histopathology, these sites of infiltration have rarely been observed on clinical examination. We studied clinical and histopathological findings of two patients with iris infiltration by primary intraocular lymphoma and reviewed the findings of 163 cases reported in the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biopsy
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Female
  • Humans
  • Iris Neoplasms / pathology*
  • Iris Neoplasms / therapy
  • Lymphoma, B-Cell / pathology*
  • Lymphoma, B-Cell / therapy
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Lymphoma, Large B-Cell, Diffuse / therapy
  • Male
  • Middle Aged
  • Visual Acuity
  • Vitreous Body / pathology