Identification of maverick, a novel member of the TGF-beta superfamily in Drosophila

Mech Dev. 2000 Jul;95(1-2):201-6. doi: 10.1016/s0925-4773(00)00338-5.


The transforming growth factor-beta (TGF-beta) superfamily of structurally related ligands regulates essential signaling pathways that control many aspects of cell behavior in organisms across the phylogenetic spectrum. Here we report the identification of maverick (mav), a gene that encodes a new member of the TGF-beta superfamily in Drosophila. Phylogenetic analysis and sequence comparison suggest that Mav cannot be easily assigned to any one sub-family, since it is equally related to BMP, activin and TGF-beta ligands. mav maps to the fourth chromosome and is expressed throughout development. In situ hybridization experiments reveal the presence of maternally derived mav transcript in precellular blastoderm embryos. Later in development, mav is expressed in a dynamic pattern in the developing gut, both in endodermal and visceral mesodermal cells. In adult females, high levels of mav mRNA are present in late stage egg chambers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary / analysis
  • DNA, Complementary / genetics
  • Drosophila / genetics*
  • Drosophila Proteins*
  • Genes, Insect*
  • Insect Proteins / genetics*
  • Molecular Sequence Data
  • Transforming Growth Factor beta / genetics*


  • DNA, Complementary
  • Drosophila Proteins
  • Insect Proteins
  • Transforming Growth Factor beta
  • mav protein, Drosophila