Pax2, Otx2, Gbx2 and Fgf8 expression in early otic vesicle development

M Hidalgo-Sánchez; R Alvarado-Mallart; I S Alvarez

doi:10.1016/s0925-4773(00)00332-4

Pax2, Otx2, Gbx2 and Fgf8 expression in early otic vesicle development

Mech Dev. 2000 Jul;95(1-2):225-9. doi: 10.1016/s0925-4773(00)00332-4.

Authors

M Hidalgo-Sánchez¹, R Alvarado-Mallart, I S Alvarez

Affiliation

¹ INSERM Unité 106, Hôpital de la Salpêtrière, 47, Bld. de l'Hôpital, 75651, Cedex 13, Paris, France.

PMID: 10906468
DOI: 10.1016/s0925-4773(00)00332-4

Abstract

The inner ear is a suitable system to study the mechanisms involved in the specification of different functional domains during morphogenesis. Using single and double in situ hybridization (ISH) we show that three transcription factors (Otx2, Gbx2and Pax2) and a member of the fibroblast growth factor family (Fgf8) could participate in the compartmentalization of the otic vesicle and in the formation of the acoustic-vestibular ganglion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chick Embryo
Ear, Inner / embryology*
Ear, Inner / physiology*
Fibroblast Growth Factor 8
Fibroblast Growth Factors / physiology*
Gene Expression Regulation, Developmental*
In Situ Hybridization
Transcription Factors / physiology*

Substances

Transcription Factors
Fibroblast Growth Factor 8
Fibroblast Growth Factors