tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish

Mech Dev. 2000 Jul;95(1-2):253-8. doi: 10.1016/s0925-4773(00)00346-4.


The T-box genes constitute a family of transcriptional regulator genes that have been implicated in a variety of developmental processes ranging from the formation of germ layers to the regionalization of the central nervous system. In this report we describe the cloning and expression pattern of a new T-box gene from zebrafish, which we named tbx20. tbx20 is an ortholog of two other T-box genes isolated from animals of different phyla - H15 of Drosophila melanogaster and tbx-12 of Caenorhabditis elegans, suggesting that the evolutionary origin of this gene predates the divergence between the protostomes and deuterostomes. During development, tbx20 is expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons, and the roof of the dorsal aorta.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System / embryology
  • Gene Expression Regulation, Developmental*
  • Molecular Sequence Data
  • Motor Neurons / physiology
  • T-Box Domain Proteins / genetics*
  • Zebrafish / embryology*
  • Zebrafish / genetics*


  • T-Box Domain Proteins