Mammalian chitinase-like proteins

EXS. 1999;87:211-21. doi: 10.1007/978-3-0348-8757-1_15.

Abstract

Mammals express genes coding for proteins that show significant similarity to chitinases of family 18 glycosyl hydrolases. These chitinase-like proteins have no chitinase activity due to changes in critical residues in the putative active center. One of these is oviductin, a high molecular weight glycoprotein most likely involved in fertilization and protection of the tubal epithelium owing to its mucin character. Another is YKL-40 (HCgp39) produced in association with tissue remodeling. Such proteins could have a general function in morphogenesis.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chitinases / chemistry*
  • Conserved Sequence
  • Glycoside Hydrolases / chemistry*
  • Glycoside Hydrolases / genetics*
  • Glycoside Hydrolases / metabolism
  • Humans
  • Mammals
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Serine Endopeptidases / chemistry

Substances

  • Glycoside Hydrolases
  • Chitinases
  • Serine Endopeptidases
  • oviductin