[Flupenthixol--a partial atypical neuroleptic?]

Fortschr Neurol Psychiatr. 2000 Apr:68 Suppl 1:S38-41.
[Article in German]

Abstract

There is no really clear-cut definition for "atypical" neuroleptics. The most convincing definition is draft by characterization of the receptor-binding profile. Most important are: the combined antagonism of D2 and 5-HT2 receptors, the preferential binding to D4 and D3 receptors and a balanced relation of D2 to D1 antagonism. Flupentixol fits into this description as well as some modern neuroleptics widely considered as "atypical" neuroleptics. Clinical criteria--like the absence of EPMS and the improvement of negative symptoms--offer no clear-cut distinction between "typical" and "atypical" neuroleptics, too, because some modern "atypical" neuroleptics lead--dose-dependent--to EPMS, and there is no proven efficacy for some atypical neuroleptics in the treatment of negative symptoms. So, neuroleptics are labelled "atypical" if there is a favourable relation between antipsychotic activity and the degree of EPMS, and if there is at least some efficacy in the treatment of negative symptoms. In this regard, Flupentixol has to be labelled at least a "partial atypical neuroleptic".

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Antipsychotic Agents / therapeutic use*
  • Dopamine Antagonists / pharmacology
  • Dopamine Antagonists / therapeutic use*
  • Flupenthixol / pharmacology
  • Flupenthixol / therapeutic use*
  • Humans
  • Receptors, Dopamine / drug effects
  • Receptors, Serotonin / drug effects
  • Schizophrenia / drug therapy*

Substances

  • Antipsychotic Agents
  • Dopamine Antagonists
  • Receptors, Dopamine
  • Receptors, Serotonin
  • Flupenthixol