Can neurological injury be timed?

Semin Perinatol. 2000 Jun;24(3):204-14. doi: 10.1053/sper.2000.7056.


Our knowledge about the cause of cerebral palsy continues to expand and prenatal events are thought to play an important role. This article reviews laboratory tests, imaging studies and pathologic findings that have been used to identify the timing of neurological injury. Limitations exist for all modalities, however, imaging studies, electroencephalograms and pathologic examination provide the most useful information. Improvements in our ability to time neurological injury will better direct our efforts to prevent cerebral palsy.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Brain / embryology
  • Brain / growth & development
  • Brain Diseases / complications
  • Brain Diseases / diagnosis*
  • Brain Diseases / diagnostic imaging
  • Cerebral Palsy / etiology*
  • Diagnostic Imaging
  • Female
  • Gestational Age
  • Heart Rate, Fetal
  • Humans
  • Hypoxia-Ischemia, Brain / complications
  • Infant, Newborn
  • Pregnancy
  • Time Factors
  • Ultrasonography, Prenatal


  • Biomarkers