Inositol addition does not improve depression in SSRI treatment failures

B Nemets; A Mishory; J Levine; R H Belmaker

doi:10.1007/s007020050200

Inositol addition does not improve depression in SSRI treatment failures

J Neural Transm (Vienna). 1999;106(7-8):795-8. doi: 10.1007/s007020050200.

Authors

B Nemets¹, A Mishory, J Levine, R H Belmaker

Affiliation

¹ Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.

PMID: 10907738
DOI: 10.1007/s007020050200

Abstract

Some antidepressants, such as Lithium, can augment the antidepressant effect of serotonin selective uptake inhibitors (SSRI) in patients who have failed to respond to SSRI. Inositol has demonstrated antidepressant effects but in a controlled double blind augmentation trial did not improve depression in SSRI treatment failures.

Publication types

Clinical Trial
Controlled Clinical Trial
Randomized Controlled Trial

MeSH terms

Adult
Aged
Depressive Disorder, Major / drug therapy*
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Inositol / therapeutic use*
Male
Middle Aged
Selective Serotonin Reuptake Inhibitors / therapeutic use*

Substances

Serotonin Uptake Inhibitors
Inositol