Inositol addition does not improve depression in SSRI treatment failures

J Neural Transm (Vienna). 1999;106(7-8):795-8. doi: 10.1007/s007020050200.


Some antidepressants, such as Lithium, can augment the antidepressant effect of serotonin selective uptake inhibitors (SSRI) in patients who have failed to respond to SSRI. Inositol has demonstrated antidepressant effects but in a controlled double blind augmentation trial did not improve depression in SSRI treatment failures.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Depressive Disorder, Major / drug therapy*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Inositol / therapeutic use*
  • Male
  • Middle Aged
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*


  • Serotonin Uptake Inhibitors
  • Inositol