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Review
. 2000 Jul 24;150(2):F83-8.
doi: 10.1083/jcb.150.2.f83.

Drosophila melanogaster G protein-coupled receptors

T Brody  1 , A Cravchik
Affiliations
Review

Drosophila melanogaster G protein-coupled receptors

T Brody et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Drosophila GPCR gene families. The newly identified GPCR genes are depicted in red. Left to right: gene name, defined transcript, closest Drosophila homologue, BLAST search e-values for the closest Drosophila (F), and C. elegans (W) and vertebrate (V) GPCRs. The # symbol indicates that the closest mammalian matches are from several different GPCR families. Previously identified Drosophila GPCRs (in black): (A) Rhodopsin-like: rhodopsins (Salcedo et al. 1999); mAcR-60C (Onai et al. 1989; Shapiro et al. 1989); dopamine receptors DopR and DopR2 (Gotzes et al. 1994; Feng et al. 1996); octopamine receptors: Ocr (Arakawa et al. 1990; Saudou et al. 1990) and Oamb (Han et al. 1998); serotonin receptors: 5-HT1A and 5-HT1B (Witz et al. 1990; Saudou et al. 1992); 5-HT2 (Colas et al. 1995) and 5-HT7 (Saudou et al. 1990); AlstR (Birgul et al. 1999); rickets (Ashburner et al. 1999); GRHR (Hauser et al. 1998); Takr99D (Li et al. 1991); Takr86C (Monnier et al. 1992); and NepYr (Li et al. 1992). (B) Secretin-like receptor: Methuselah (Lin et al. 1998). (C) Metabotropic glutamate receptor: Glu-RA (Parmentier et al. 1996).
Figure 2
Figure 2
Phylogeny tree of the Methuselah-like subfamily performed using the neighbor-joining method.
Figure 3
Figure 3
Multiple sequence alignment of the mth-like receptors performed using Clustal X. The topology of the seven putative TM domains is indicated.
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