Serum Tryptase and the Laboratory Diagnosis of Systemic Mastocytosis

Hematol Oncol Clin North Am. 2000 Jun;14(3):641-57. doi: 10.1016/s0889-8588(05)70300-2.

Abstract

Total tryptase levels of 20 ng/mL or higher in a baseline serum sample when the ratio of total to beta-tryptase is 20 or greater strongly suggest underlying systemic mastocytosis. Whether these criteria prove to be more sensitive than a bone marrow biopsy will require further study. Although the absolute level of total tryptase does not predict disease severity, it may provide a practical method for assessing the efficacy of therapeutic interventions designed to reduce the mast cell burden.

Publication types

  • Review

MeSH terms

  • Anaphylaxis / enzymology
  • Animals
  • Biomarkers
  • Enzyme Induction
  • Enzyme Precursors / genetics
  • Enzyme Precursors / metabolism
  • Genes
  • Humans
  • Isoenzymes / blood*
  • Isoenzymes / genetics
  • Mammals / metabolism
  • Mast Cells / classification
  • Mast Cells / enzymology
  • Mastocytosis / diagnosis*
  • Mastocytosis / enzymology
  • Mastocytosis / genetics
  • Postmortem Changes
  • Protein Processing, Post-Translational
  • Retrospective Studies
  • Serine Endopeptidases / blood*
  • Serine Endopeptidases / genetics
  • Sudden Infant Death / etiology
  • Tryptases

Substances

  • Biomarkers
  • Enzyme Precursors
  • Isoenzymes
  • Serine Endopeptidases
  • Tryptases