Physiological modeling with virtual cell framework

Methods Enzymol. 2000:321:1-23. doi: 10.1016/s0076-6879(00)21184-1.


This article describes a computational framework for cell biological modeling and simulation that is based on the mapping of experimental biochemical and electrophysiological data onto experimental images. The framework is designed to enable the construction of complex general models that encompass the general class of problems coupling reaction and diffusion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcium / metabolism
  • Computer Simulation*
  • Electrophysiology
  • Models, Biological*
  • Models, Theoretical
  • Software
  • Xenopus / embryology


  • Calcium