Reactive arthritis

Curr Opin Rheumatol. 2000 Jul;12(4):300-5. doi: 10.1097/00002281-200007000-00012.


During the past year, no big advances were reported in understanding the pathogenesis or treatment of reactive arthritis (ReA). The need for generally accepted diagnostic criteria has become a central issue. Regarding pathogenesis, attention has been drawn to a similarity between ReA and the experimental antigen-induced arthritis. Molecular mechanisms of the HLA-B27-associated pathogenesis have remained, in spite of intensive research, so far a mystery. It is apparent that antibiotics have no effect on the fully developed reactive arthritis, with the exception of patients with Chlamydia-triggered ReA, who might benefit from a course of antibiotics.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Arthritis, Reactive* / blood
  • Arthritis, Reactive* / classification
  • Arthritis, Reactive* / drug therapy
  • Arthritis, Reactive* / microbiology
  • Chlamydia Infections / microbiology
  • Chlamydia trachomatis / genetics
  • Chlamydia trachomatis / isolation & purification
  • Ciprofloxacin / therapeutic use
  • DNA, Bacterial / analysis
  • Double-Blind Method
  • HLA-B27 Antigen / blood
  • Humans
  • Randomized Controlled Trials as Topic
  • Yersinia Infections / microbiology
  • Yersinia enterocolitica / genetics
  • Yersinia enterocolitica / isolation & purification


  • DNA, Bacterial
  • HLA-B27 Antigen
  • Ciprofloxacin