Effects of intravascular clotting on the activation of the complement system: The role of the platelet

Am J Pathol. 1975 Mar;78(3):525-36.


Total hemolytic complement activity and the third component of complement were found to be significantly depressed in vivo in rabbits following the induction of disseminated intravascular coagulation by both thrombin and thromboplastin. Production of severe thrombocytopenia by the administration of platelet antiserum prior to the infusion of thrombin or thromboplastin partially prevented complement activation. The data show that, when clotting is triggered, complement activation takes place and that platelets are required to some extent for this reaction.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigen-Antibody Complex
  • Blood Platelets / drug effects
  • Blood Platelets / physiology*
  • Cattle
  • Complement System Proteins*
  • Disseminated Intravascular Coagulation / blood*
  • Disseminated Intravascular Coagulation / etiology
  • Disseminated Intravascular Coagulation / immunology
  • Endotoxins
  • Escherichia coli / immunology
  • Female
  • Goats / immunology
  • Hemolysis
  • Immune Sera
  • Infusions, Parenteral
  • Male
  • Rabbits
  • Sodium Chloride / pharmacology
  • Thrombin / pharmacology
  • Thromboplastin / pharmacology


  • Antigen-Antibody Complex
  • Endotoxins
  • Immune Sera
  • Sodium Chloride
  • Complement System Proteins
  • Thromboplastin
  • Thrombin