FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis

Mol Cell. 2000 Jun;5(6):1003-11. doi: 10.1016/s1097-2765(00)80265-8.

Abstract

Flagellin, the main protein of the bacterial flagella, elicits defence responses and alters growth in Arabidopsis seedlings. Previously, we identified the FLS1 locus, which confers flagellin insensitivity in Ws-0. To identify additional components involved in flagellin perception, we screened for flagellin insensitivity mutants in the flagellin-sensitive accession La-er. Here, we describe the identification of a new locus, FLS2, by a map-based strategy. The FLS2 gene is ubiquitously expressed and encodes a putative receptor kinase. FLS2 shares structural and functional homologies with known plant resistance genes and with components involved in the innate immune system of mammals and insects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis / drug effects*
  • Arabidopsis / enzymology*
  • Arabidopsis / genetics
  • Arabidopsis / growth & development
  • Arabidopsis Proteins*
  • Cloning, Molecular
  • Flagellin / pharmacology*
  • Gene Expression Profiling
  • Genes, Plant / genetics
  • Genetic Complementation Test
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Molecular Sequence Data
  • Mutation / genetics
  • Phenotype
  • Plant Proteins / chemistry
  • Plant Proteins / genetics
  • Plant Proteins / metabolism
  • Plants, Genetically Modified
  • Protein Kinases / chemistry
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • Proteins / chemistry
  • Proteins / genetics
  • Proteins / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Respiratory Burst
  • Signal Transduction / drug effects

Substances

  • Arabidopsis Proteins
  • Membrane Proteins
  • Plant Proteins
  • Proteins
  • RNA, Messenger
  • leucine-rich repeat proteins
  • Flagellin
  • Protein Kinases
  • FLS2 protein, Arabidopsis

Associated data

  • GENBANK/AB010698