Effects of IGFBP-2 overexpression in vitro and in vivo

Pediatr Nephrol. 2000 Jul;14(7):572-8. doi: 10.1007/s004670000362.


Insulin-like growth factor-binding proteins (IGFBPs) are important modulators of IGF actions and may have both stimulatory and inhibitory effects. Expression of IGFBP-2 is increased after fasting and in a variety of pathological conditions. However, the specific role of IGFBP-2 in growth physiology remains to be determined. In this review, we summarize data from in vitro and in vivo models suggesting that IGFBP-2 has mainly inhibitory effects on IGF actions. Since the growth hormone (GH)/IGF system is involved in a number of pathological alterations of the kidney and these changes may--at least in part--be due to increased IGF-I, local overexpression of inhibitory IGFBP-2 in the kidney might prevent IGF-I-induced lesions. This hypothesis will be tested by crossing GH transgenic mice, a common model of glomerulosclerosis, with transgenic mice characterized by systemic and renal overexpression of IGFBP-2.

Publication types

  • Review

MeSH terms

  • Animals
  • Cells, Cultured / metabolism
  • Growth Hormone / physiology
  • Humans
  • In Vitro Techniques
  • Insulin-Like Growth Factor Binding Protein 2 / metabolism*
  • Kidney / metabolism
  • Kidney Diseases / physiopathology*
  • Liver Diseases / metabolism
  • Lung Diseases / metabolism
  • Neoplasms / metabolism
  • Somatomedins / physiology


  • Insulin-Like Growth Factor Binding Protein 2
  • Somatomedins
  • Growth Hormone