Age-group differences in treatment outcomes for male veterans with severe schizophrenia: a three-year longitudinal study

J Geriatr Psychiatry Neurol. 2000 Summer;13(2):78-86. doi: 10.1177/089198870001300206.


Treatment outcomes in later-life schizophrenia are poorly understood and of serious concern for clinicians and mental health policy makers. Age-group differences were examined for 499 male veterans with severe schizophrenia enrolled in enhanced treatment programs at 12 Veterans Affairs hospitals. Participants were separated into three age groups (20-39 years, 40-59 years, 60 years and above), with the following outcomes assessed at enrolment and 1 and 3 years afterwards: psychiatric symptomatology, global functioning, impairment in Instrumental Activities of Daily Living (IADL), and hospital use. All three age groups experienced significant improvement in psychiatric symptoms over time. The oldest group fared worse than younger patients in terms of global functioning and generally required more inpatient services and assistance with IADL. Innovative programming is needed to meet the special needs of the growing population of older adults with schizophrenia.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Geriatric Psychiatry
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Prognosis
  • Schizophrenia / drug therapy*
  • Schizophrenia / pathology
  • Treatment Outcome
  • Veterans*