Effect of salbutamol on muscle strength and endurance performance in nonasthmatic men

Med Sci Sports Exerc. 2000 Jul;32(7):1300-6. doi: 10.1097/00005768-200007000-00018.


Purpose: The ergogenic effect of acute beta2-adrenergic agonist administration in nonasthmatic individuals has not been clearly demonstrated. Therefore, the acute effects of oral administration of the beta2-adrenergic agonist salbutamol (4 mg) on muscle strength and endurance performance were studied in 16 nonasthmatic men in a double-blind randomized cross-over study.

Methods: Peak expiratory flow (Mini Wright Peakflowmeter), isokinetic strength of the knee extensors and knee flexors at four angular velocities (Cybex II dynamometer), and endurance performance in a cycle ergometer test until exhaustion at 70% of maximal workload were measured.

Results: Peak expiratory flow increased from 601 +/- 67 L x min(-1) to 629 +/- 64 L x min(-1) after salbutamol (P < 0.05). Peak torque was higher after salbutamol than after placebo (4.4% for the knee extensors, 4.9% for the knee flexors) (P < 0.05). Mean endurance time increased from 3,039 +/- 1,031 s after placebo to 3,439 +/- 1,287 s after salbutamol (P = 0.19). When four subjects complaining about adverse side effects were excluded from the analysis, the increase in endurance time (729 +/- 1,007 s or 29%) was statistically significant (P <-0.05). Salbutamol did not affect VO2, respiratory exchange ratio, heart rate, and plasma free fatty acid and glycerol concentration during exercise; plasma lactate and potassium concentrations were increased (P < 0.05).

Conclusions: Under the conditions of this study, oral salbutamol appears to be an effective ergogenic aid in nonasthmatic individuals not experiencing adverse side effects.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Albuterol / administration & dosage
  • Albuterol / pharmacology*
  • Bronchodilator Agents / administration & dosage
  • Bronchodilator Agents / pharmacology*
  • Double-Blind Method
  • Ergometry
  • Heart Rate
  • Humans
  • Lactic Acid / analysis
  • Male
  • Muscle Contraction / drug effects*
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / physiology
  • Physical Endurance / drug effects*
  • Potassium / analysis


  • Bronchodilator Agents
  • Lactic Acid
  • Albuterol
  • Potassium