Elucidating a biological role for chromium at a molecular level

Acc Chem Res. 2000 Jul;33(7):503-10. doi: 10.1021/ar990073r.


Chromium is an essential trace element for mammals and is required for maintenance of proper carbohydrate and lipid metabolism. However, elucidating its function at a molecular level has proved to be problematic. Recent research has revealed that the chromium-binding oligopeptide chromodulin may play a unique role in the autoamplification of insulin signaling. Attempts to develop chromium-containing nutritional supplements and therapeutics are described.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Carbohydrate Metabolism
  • Cardiovascular Diseases / metabolism
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Chromium / physiology*
  • Diabetes Mellitus / metabolism
  • Humans
  • Lipid Metabolism
  • Picolinic Acids / metabolism*


  • Carrier Proteins
  • Picolinic Acids
  • chromodulin protein, human
  • chromodulin protein, mouse
  • Chromium
  • picolinic acid