Parallel synthesis and evaluation of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines as Na+/K+ ATPase inhibitors

Bioorg Med Chem Lett. 2000 Jul 17;10(14):1543-5. doi: 10.1016/s0960-894x(00)00296-1.

Abstract

A series of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines was prepared using solution-phase, parallel synthesis and evaluated for Na+/K+ ATPase inhibition.

MeSH terms

  • Amines / chemical synthesis*
  • Amines / chemistry
  • Amines / pharmacology
  • Animals
  • Dogs
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Imidazoles / pharmacology
  • Indicators and Reagents
  • Kinetics
  • Molecular Conformation
  • Molecular Structure
  • Myocardium / enzymology
  • Sarcolemma / enzymology
  • Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*

Substances

  • Amines
  • Enzyme Inhibitors
  • Imidazoles
  • Indicators and Reagents
  • Sodium-Potassium-Exchanging ATPase