Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase

R M Dunsdon; J R Greening; P S Jones; S Jordan; F X Wilson

doi:10.1016/s0960-894x(00)00284-5

Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase

Bioorg Med Chem Lett. 2000 Jul 17;10(14):1577-9. doi: 10.1016/s0960-894x(00)00284-5.

Authors

R M Dunsdon¹, J R Greening, P S Jones, S Jordan, F X Wilson

Affiliation

¹ Department of Medicinal Chemistry, Roche Discovery Welwyn, Welwyn Garden City, Herts, UK.

PMID: 10915055
DOI: 10.1016/s0960-894x(00)00284-5

Abstract

Use of a resin bound diol as a boronic acid protecting group has been developed to allow the parallel synthesis of potent inhibitors of the hepatitis C virus NS3 serine proteinase.

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Boronic Acids / chemical synthesis*
Boronic Acids / chemistry
Boronic Acids / pharmacology
Drug Design
Hepacivirus / drug effects
Hepacivirus / enzymology*
Indicators and Reagents
Molecular Structure
RNA Helicases
Serine Endopeptidases
Serine Proteinase Inhibitors / chemical synthesis*
Serine Proteinase Inhibitors / chemistry
Serine Proteinase Inhibitors / pharmacology
Structure-Activity Relationship
Viral Nonstructural Proteins / antagonists & inhibitors*

Substances

Antiviral Agents
Boronic Acids
Indicators and Reagents
NS3 protein, flavivirus
Serine Proteinase Inhibitors
Viral Nonstructural Proteins
Serine Endopeptidases
RNA Helicases