Maturation of cellular Fe-S proteins: an essential function of mitochondria

Trends Biochem Sci. 2000 Aug;25(8):352-6. doi: 10.1016/s0968-0004(00)01589-9.


Iron-sulfur (Fe-S) cluster-containing proteins perform important tasks in catalysis, electron transfer and regulation of gene expression. In eukaryotes, mitochondria are the primary site of cluster formation of most Fe-S proteins. Assembly of the Fe-S clusters is mediated by the iron-sulphate cluster assembly (ISC) machinery consisting of some ten proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport
  • Evolution, Molecular
  • Humans
  • Iron-Sulfur Proteins / biosynthesis*
  • Iron-Sulfur Proteins / metabolism
  • Mitochondria / genetics
  • Mitochondria / metabolism*
  • Models, Biological
  • Saccharomyces cerevisiae / metabolism


  • Iron-Sulfur Proteins