Control of elongation by RNA polymerase II

Trends Biochem Sci. 2000 Aug;25(8):375-80. doi: 10.1016/s0968-0004(00)01615-7.

Abstract

The elongation stage of eukaryotic mRNA synthesis can be regulated by transcription factors that interact directly with the RNA polymerase II (pol II) elongation complex and by activities that modulate the structure of its chromatin template. Recent studies have revealed new elongation factors and have implicated the general initiation factors TFIIE, TFIIF and TFIIH, as well as the C-terminal domain (CTD) of the largest subunit of pol II, in elongation. The recently reported high-resolution crystal structure of RNA polymerase II, which provides insight into the architecture of the elongation complex, marks a new era of investigation into transcription elongation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Chromatin / metabolism
  • Gene Expression Regulation
  • Models, Biological
  • RNA Polymerase II / chemistry*
  • RNA Polymerase II / genetics
  • RNA Polymerase II / metabolism*
  • RNA, Messenger / biosynthesis*
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • RNA, Messenger
  • Transcription Factors
  • RNA Polymerase II