AMP-activated protein kinase: a critical signaling intermediary for exercise-stimulated glucose transport?

Exerc Sport Sci Rev. 2000 Jul;28(3):113-6.

Abstract

Physical exercise increases the rate of glucose transport into contracting skeletal muscles by a mechanism that involves translocation of the GLUT4 glucose transporter to the cell surface. This brief report will discuss an emerging hypothesis that suggests that the AMP-activated protein kinase is a key signaling intermediary leading to exercise-stimulated GLUT4 translocation in skeletal muscle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • AMP-Activated Protein Kinases
  • Biological Transport
  • Exercise / physiology*
  • Glucose / metabolism*
  • Humans
  • Monosaccharide Transport Proteins / physiology
  • Multienzyme Complexes / metabolism*
  • Muscle Contraction
  • Muscle, Skeletal / physiology*
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction

Substances

  • Monosaccharide Transport Proteins
  • Multienzyme Complexes
  • Protein Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • Glucose