The problem and implications of chloramphenicol resistance in the typhoid bacillus

J Hyg (Lond). 1975 Apr;74(2):289-99. doi: 10.1017/s0022172400024360.


Transferable chloramphenicol resistance has become common in the typhoid bacillus in countries such as Mexico, India, Vietnam and Thailand. Situations such as this, and others analogous to it in many parts of the world, are the result of the long-term indiscriminate use of chloramphenicol and other antibiotics in the affected areas. They can be rectified only by more rational antibiotic usage.

MeSH terms

  • Bacteriophage Typing
  • Chloramphenicol* / pharmacology
  • Chromosomes, Bacterial
  • Conjugation, Genetic*
  • DNA, Bacterial
  • Drug Resistance, Microbial*
  • Escherichia coli
  • Extrachromosomal Inheritance*
  • Humans
  • Salmonella Phages
  • Salmonella typhi* / drug effects
  • Salmonella typhimurium / drug effects


  • DNA, Bacterial
  • Chloramphenicol