Hyperventilation associated with quetiapine

Ann Pharmacother. 2000 Mar;34(3):335-7. doi: 10.1345/aph.19232.

Abstract

Objective: To describe a case of hyperventilation associated with the administration of quetiapine.

Case summary: A 69-year-old African-American woman admitted to a psychiatric hospital for treatment of major depression with psychotic features was treated and successfully discharged with quetiapine, along with metronidazole and miconazole to treat bacterial/monilial vaginitis. Three days after discharge, the patient presented to a community hospital with shortness of breath and hyperventilation. The patient was admitted and treated for tachypnea and acute respiratory alkalosis. During this hospitalization, the patient was noted to have increased respiratory rate following the administration of quetiapine.

Discussion: Hyperventilation was reported during the clinical trials of quetiapine; however, this is the first published report to date. Serotonin is involved both centrally and peripherally in the regulation of respiration. A contributing factor in this case may have been the concomitant administration of metronidazole, which inhibits the cytochrome P450 enzyme (CYP3A4) also responsible for the metabolism of quetiapine.

Conclusions: The development of hyperventilation and respiratory alkalosis was associated with the administration of quetiapine.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Alkalosis, Respiratory / blood
  • Alkalosis, Respiratory / chemically induced
  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Antitrichomonal Agents / adverse effects
  • Depressive Disorder / complications*
  • Depressive Disorder / drug therapy
  • Dibenzothiazepines / adverse effects*
  • Dibenzothiazepines / therapeutic use
  • Drug Interactions
  • Female
  • Humans
  • Hyperventilation / chemically induced*
  • Metronidazole / adverse effects
  • Quetiapine Fumarate

Substances

  • Antipsychotic Agents
  • Antitrichomonal Agents
  • Dibenzothiazepines
  • Metronidazole
  • Quetiapine Fumarate