Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer

Br J Cancer. 2000 Aug;83(3):384-6. doi: 10.1054/bjoc.2000.1239.


BRCA1/2 mutation carriers diagnosed with breast cancer have a strongly elevated life-time risk of developing a contralateral tumour. We studied the contralateral breast cancer risk in 164 patients from 83 families with a proven BRCA1 mutation in relation to the age at diagnosis of the first primary breast cancer. In the actuarial outcomes after 10 years' follow-up, 40% of the 124 BRCA1-patients diagnosed with breast cancer < 50 years had developed contralateral breast cancer, vs 12% of the 40 patients > 50 years at first diagnosis (Plogrank = 0.02). These data suggest that age at diagnosis of the first tumour should be taken into account when prophylactic mastectomy in BRCA1-patients is considered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset*
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / etiology*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / mortality
  • Female
  • Genes, BRCA1 / genetics*
  • Humans
  • Incidence
  • Middle Aged
  • Mutation*
  • Neoplasms, Second Primary / epidemiology
  • Netherlands / epidemiology
  • Risk
  • Risk Factors
  • Survival Rate