Comparison of the quantification precision of human short echo time (1)H spectroscopy at 1.5 and 4.0 Tesla

Magn Reson Med. 2000 Aug;44(2):185-92. doi: 10.1002/1522-2594(200008)44:2<185::aid-mrm4>;2-v.


Precise quantification of human in vivo short echo time (1)H spectra remains problematic at clinical field strengths due to broad peak linewidths and low signal-to-noise ratio (SNR). In this study, multiple STEAM spectra (TE = 20 ms, volume = 8 cm(3)) were acquired in a single individual at 1.5 T and 4 T to compare quantification precision. Test-retest STEAM spectra (volume = 1.5 cm(3)) were also acquired from the anterior cingulate and thalamus of 10 individuals at 4.0 T. Metabolite levels were quantified using automated software that incorporated field strength-specific prior knowledge. With the distinct methods of data acquisition, processing, and fitting used in this study, peak height SNR increased approximately 80% while peak linewidth increased by approximately 50% in the 8 cm(3) volumes at 4.0 T compared to 1.5 T, resulting in an average increase in quantification precision of 39%. Metabolite levels from test-retest data (1.5 cm(3) voxels at 4.0 T) were quantified with similar inter- and intraindividual variability. Magn Reson Med 44:185-192, 2000. Published 2000 Wiley-Liss, Inc.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain / metabolism*
  • Gyrus Cinguli / metabolism
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Parietal Lobe / metabolism
  • Reproducibility of Results
  • Signal Processing, Computer-Assisted
  • Software
  • Thalamus / metabolism