Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis

Oncogene. 2000 Jul 6;19(29):3256-65. doi: 10.1038/sj.onc.1203654.


Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression. We used the well-characterized Rat1AmycERT cells to show that the caveolin-1 gene is down-regulated at the level of transcription by c-myc. By maintaining relatively high levels of caveolin-1 with an adenoviral vector or in stably transfected clones we show that caveolin-1 can suppress c-myc-induced apoptosis. Further we established human prostate cancer cell lines with the mycER construct and show that clones with increased caveolin-1 are more resistant to myc-induced apoptosis and have increased capacity for growth in soft agar when c-myc is activated.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apoptosis*
  • Caveolin 1
  • Caveolins*
  • Cell Line
  • Down-Regulation*
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Prostatic Neoplasms / physiopathology
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism*
  • Rats


  • CAV1 protein, human
  • Cav1 protein, rat
  • Caveolin 1
  • Caveolins
  • Membrane Proteins
  • Proto-Oncogene Proteins c-myc