Steroid regulation of postembryonic development and reproduction in Drosophila

Trends Endocrinol Metab. 2000 Sep;11(7):276-80. doi: 10.1016/s1043-2760(00)00282-4.


Ecdysteroids trigger major developmental transitions in Drosophila, including larval molts and metamorphosis. Recent genetic studies strongly support a role for the Ecdysteroid receptor (EcR)/Ultraspiracle (USP) heterodimer as an ecdysteroid receptor at the onset of metamorphosis, functioning as both a transcriptional activator and repressor in vivo. Genetic analysis also indicates that USP, like its vertebrate homolog retinoid X receptor (RXR), might be involved in regulatory pathways independently of EcR. The ecdysteroid hierarchy was also shown recently to regulate Drosophila oogenesis and reproduction.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila / genetics
  • Drosophila / physiology*
  • Embryonic Development*
  • Reproduction / physiology*
  • Signal Transduction / genetics
  • Steroids / physiology*
  • Transcription, Genetic / genetics


  • Steroids