Objective: To evaluate the long term results of intravesical nocardia rubre cell wall skeleton instillation to prevent recurrence after surgery for bladder cancer.
Methods: A randomized and placedo-controlled trial on intravesical N-CWS instillation versus mitomycin-C(MMC) therapy for recurrence prevention in postopenative bladder cancer patients was carried out.
Results: Fourty-five patients were treated with N-CWS with 39 followed for 12 to 60 months. Thirteen patients developed recurrence. The 1-year tumor free survival rate was 87.2% and that at 5 years was 66.7%. Thirty patients as treated with MMC serving as controll with 25 followed for the same duration, twelve patients developed recurrence. The 1-year tumor free survival rate was 84% and that at 5 years was 52%. The results indicate that N-CWS gave better results with rare and milder side effects.
Conclusion: N-CWS is believed to be one of the effective drugs in preventing bladder cancer recurrence after surgery.