[Long-term results of intravesical N-CWS instillation to prevent recurrence after surgery for bladder cancer]

Zhonghua Zhong Liu Za Zhi. 1997 May;19(3):228-30.
[Article in Chinese]

Abstract

Objective: To evaluate the long term results of intravesical nocardia rubre cell wall skeleton instillation to prevent recurrence after surgery for bladder cancer.

Methods: A randomized and placedo-controlled trial on intravesical N-CWS instillation versus mitomycin-C(MMC) therapy for recurrence prevention in postopenative bladder cancer patients was carried out.

Results: Fourty-five patients were treated with N-CWS with 39 followed for 12 to 60 months. Thirteen patients developed recurrence. The 1-year tumor free survival rate was 87.2% and that at 5 years was 66.7%. Thirty patients as treated with MMC serving as controll with 25 followed for the same duration, twelve patients developed recurrence. The 1-year tumor free survival rate was 84% and that at 5 years was 52%. The results indicate that N-CWS gave better results with rare and milder side effects.

Conclusion: N-CWS is believed to be one of the effective drugs in preventing bladder cancer recurrence after surgery.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Administration, Intravesical
  • Adult
  • Aged
  • Antibiotics, Antineoplastic / therapeutic use
  • Carcinoma, Transitional Cell / surgery
  • Carcinoma, Transitional Cell / therapy*
  • Cell Wall Skeleton / therapeutic use*
  • Cystectomy / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Mitomycin / therapeutic use
  • Neoplasm Recurrence, Local / prevention & control*
  • Nocardia
  • Postoperative Period
  • Survival Rate
  • Urinary Bladder / surgery
  • Urinary Bladder Neoplasms / surgery
  • Urinary Bladder Neoplasms / therapy*

Substances

  • Adjuvants, Immunologic
  • Antibiotics, Antineoplastic
  • Cell Wall Skeleton
  • cell wall skeleton, Nocardia
  • Mitomycin