Purpose: To study the time-effect relationship of action of acupuncture on the satiety center of ventromedial nucleus of hypothalamus (VMH) in rats with experimental obesity.
Methods: Microelectrode recording method of nerve cells and stereotaxic technique for brain were adopted with discharge frequency (Hz/s) of nerve impulse in VMH as the index, and the time-effect of acupuncture action in different periods between groups were observed.
Results: Electric activity in acupuncture group was higher than in the obesity model group (P < 0.001) and the normal group (P < 0.01) respectively, and the curve of acupuncture action within 2 hours showed irregular fluctuation.
Conclusion: Acupuncture can increase excitability of the satiety center, with a better long-term effect.