Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses

Br J Vener Dis. 1975 Feb;51(1):51-3. doi: 10.1136/sti.51.1.51.


Serum concentrations of tinidazole and metronidazole have been measured in healthy female volunteers who received a single dose of 2 g. of each drug in a cross-over study. Bioassays against T. vaginalis showed that metronidazole achieved higher peak concentrations (mean 81 mug./ml.) than did tinidazole (mean 67 mug./ml.), while assays for unchanged drug showed higher peak concentrations of tinidazole )mean 51 mug./ml;) than of metronidazole (mean 40 mug./ml9). This discrepancy is probably due to the presence in the serum of active metabolites of metronidazole. The longer half-life of tinidazole led to significantly higher serum concentrations (by bioassay and chemical assay) of tinidazole than of metronidazole from 6 hrs onwards.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Administration, Oral
  • Azoles / blood
  • Biological Availability
  • Clinical Trials as Topic
  • Female
  • Half-Life
  • Humans
  • Kinetics
  • Metronidazole / administration & dosage
  • Metronidazole / blood
  • Metronidazole / pharmacology*
  • Nitroimidazoles / pharmacology*
  • Structure-Activity Relationship
  • Tinidazole / administration & dosage
  • Tinidazole / pharmacology*


  • Azoles
  • Nitroimidazoles
  • Tinidazole
  • Metronidazole